Status:

COMPLETED

Salbutamol, Pharmacogenetics and Breathing Mechanics

Lead Sponsor:

University of British Columbia

Collaborating Sponsors:

World Anti-Doping Agency

Conditions:

Bronchoconstriction

Inhaled Salbutamol

Eligibility:

All Genders

19-45 years

Phase:

PHASE4

Brief Summary

Athletes using asthma medications called β2-agonists win a disproportionately high number of medals at Olympic Games. Due to a large variety in the genes that affect how individuals respond to β2-agon...

Eligibility Criteria

Inclusion

  • trained, experienced cyclists
  • maximal oxygen consumption of at least 50ml/kg/min or 4l/min for women; and 60ml/kg/min or 5l/min for men
  • athletes with and without exercise-induced bronchoconstriction

Exclusion

  • any uncontrolled heart or lung condition
  • maximal oxygen consumption of less than 50ml/kg/min or 4L/min for women; and less than 60ml/kg/min or 5L/min for men
  • pregnancy
  • smoking

Key Trial Info

Start Date :

May 1 2013

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

August 1 2016

Estimated Enrollment :

94 Patients enrolled

Trial Details

Trial ID

NCT01903785

Start Date

May 1 2013

End Date

August 1 2016

Last Update

November 2 2016

Active Locations (1)

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1

Environmental Physiology Laboratory, University of British Columbia

Vancouver, British Columbia, Canada, V6T 1Z1