Status:
TERMINATED
The Role of S-nitrosohemoglobin in Regulating Systemic Blood Flow During Hypoxia and Normoxia
Lead Sponsor:
Duke University
Conditions:
Focus is Determination of the Role of SNO-Hb in Forearm Blood Flow Regulation
Eligibility:
All Genders
18-40 years
Phase:
EARLY_PHASE1
Brief Summary
Nitric oxide is believed to contribute to regulation of blood flow by its selective binding to circulating hemoglobin (forming S-nitrosohemoglobin, SNO-Hb) and release in a PO2-dependent manner. This ...
Detailed Description
NO has been shown to associate with erythrocytes in the form of SNO-Hb and can deliver vasomotor changes as erythrocytes pass through a physiologic O2 gradient. The aim of this study is to transiently...
Eligibility Criteria
Inclusion
- Healthy volunteers
Exclusion
- Pregnancy
- smoking
- pulmonary disease
- cardiovascular disease
Key Trial Info
Start Date :
March 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2013
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT01905696
Start Date
March 1 2013
End Date
August 1 2013
Last Update
December 29 2016
Active Locations (1)
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1
Duke University Medical Center
Durham, North Carolina, United States, 27710