Status:
TERMINATED
Lung and Systemic Inflammation in the Critically Ill Patient
Lead Sponsor:
Rigshospitalet, Denmark
Conditions:
Acute Respiratory Distress Syndrome (ARDS)
Systemic Inflammatory Response Syndrome (SIRS)
Eligibility:
All Genders
18+ years
Brief Summary
Acute respiratory distress syndrome (ARDS) is a devastating form of acute lung inflammation, that may be caused by a variety of insults with pulmonary and systemic infectious disease being the most co...
Eligibility Criteria
Inclusion
- General:
- Age \>18 years
- Mechanically ventilated
- \< 48 hours after admission to the Intensive Care Unit
- Specific:
- ARDS: acute (\< 1 week) respiratory failure, characterized by hypoxemia (PaO2/FiO2 \< 300 mmHg/40kPa), and bilateral infiltrates on x-ray or CT of thorax, that can not be explained by heart failure og overhydration.
- OR
- \- SIRS (two of the following): Temperature \> 38°C or \< 36°C, heart rate \> 90/min, respiratory frequency \> 20 or PaCO2 \< 4.2 kPa, leukocytosis (\> 12x10\^9/L) or leukopenia (\< 4x10\^9/L)
- OR
- ARDS + SIRS
Exclusion
- One lung ventilation; Tube size \< 8.0 mm; INR \> 1.5 or thrombocytes \< 40x10\^9/L; Intracranial hypertension; Malignant arrythmias
Key Trial Info
Start Date :
July 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2018
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT01906229
Start Date
July 1 2013
End Date
December 1 2018
Last Update
December 11 2018
Active Locations (1)
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1
Intensive Care Unit, 4131, Rigshospitalet
Copenhagen Ø, Denmark, 2100