Status:
WITHDRAWN
Cardiac Fibrosis by CMR in Patients With Cancer
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Lymphoma
Eligibility:
All Genders
18+ years
Brief Summary
A study to test the effectiveness of an investigational imaging technique for detecting cardiac injury after the administration of certain chemotherapies, such as doxorubicin. "Investigational" means ...
Detailed Description
If you choose to take part in this study, we will ask you to sign this consent form before we do any study procedures. All participants will come in for a CMR scan prior to their first treatment with ...
Eligibility Criteria
Inclusion
- Aged ≥ 18 and able to give consent
- New diagnosis of lymphoma and scheduled to undergo doxorubicin (DOX)-based chemotherapy.
Exclusion
- Concurrent radiotherapy prior to the performance of both CMR studies, however consolidative radiotherapy after the completion of DOX and after the acquisition of the second CMR study is acceptable
- No prior malignancy treated with chemotherapy or mediastinal radiotherapy
- No contraindications to the performance of a magnetic resonance study:
- The presence of an implanted metallic object such as a cardiac pacemaker or implantable defibrillator
- An implanted neural stimulator
- Any ferromagnetic implants not deemed MRI-safe
- Intra-ocular metallic foreign bodies
- Severe claustrophobia
- Pregnancy
- Inability to perform an exercise test
- Glomerular filtration rate \< 60 ml/min/1.73 m2
Key Trial Info
Start Date :
March 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 25 2018
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01906437
Start Date
March 1 2013
End Date
August 25 2018
Last Update
September 14 2018
Active Locations (3)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
2
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02215
3
Dana Farber Cancer Insitute
Boston, Massachusetts, United States, 02215