Status:
COMPLETED
Plasma and Urine TMAO Formation and Changes to Oxidized LDL After Ingestion of Different Amounts of Egg
Lead Sponsor:
University of North Carolina, Chapel Hill
Collaborating Sponsors:
American Egg Board
Conditions:
Biomarkers of Cardiovascular Disease
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Eggs contain an essential nutrient called choline and adequate levels of choline are required for good health. Studies in mice have demonstrated that high levels of choline may increase risk of heart ...
Detailed Description
Diets low in choline have adverse health consequences, while observations in humans and experiments in mouse models suggest that a diet containing too much choline or phosphatidylcholine may activate ...
Eligibility Criteria
Inclusion
- Healthy
- non-smoker
- Body mass index between 20 to 39 kg/m²
Exclusion
- History of chronic system disease/s (e.g., hepatic, renal, cardiovascular, intestinal)
- Diabetes controlled by insulin
- Alcohol or illegal drug misuse/abuse
- Use of antibiotics or choline-containing supplements within three months of study
- Allergies to soy, eggs, wheat or other food
- Use of drugs or medications known to alter liver metabolism, cardiovascular and/or kidney function
- Abnormal physical examination or abnormal clinical laboratory values
- Pregnancy
- Unusual dietary habits
Key Trial Info
Start Date :
October 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2013
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT01906554
Start Date
October 1 2012
End Date
July 1 2013
Last Update
July 24 2013
Active Locations (1)
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1
University of North Carolina at Chapel Hill Nutrition Research Institute
Kannapolis, North Carolina, United States, 28081