Status:
UNKNOWN
Triple Therapy Versus Quadruple Therapies in the First Line Therapy of Helicobacter Pylori Infection
Lead Sponsor:
National Taiwan University Hospital
Conditions:
Helicobacter Pylori Infection
Eligibility:
All Genders
20+ years
Phase:
PHASE4
Brief Summary
Whether non-bismuth quadruple therapy (concomitant therapy) is more effective than bismuth quadruple therapy or triple therapy for 14 days remains unknown. Therefore, we aim to compare the eradicatio...
Detailed Description
First line therapy: open labeled, randomized control trial, randomized into one of the three groups Group (A): triple therapy for 14 days D1-D14: (lansoprazole 30mg + clarithromycin 500mg + amoxicilli...
Eligibility Criteria
Inclusion
- Patients aged greater than 20 years who have H. pylori infection without prior eradication therapy and are willing to receive the sequential therapy will be eligible for enrolment. Written informed consents will be obtained from all patients prior to enrollment.
Exclusion
- Patients will be excluded from the study if any one of the following criteria is present: (1) children and teenagers aged less than 20 years, (2) history of gastrectomy, (3)gastric malignancy, including adenocarcinoma and lymphoma, (4) previous allergic reaction to antibiotics (amoxicillin, clarithromycin, metronidazole, or levofloxacin) and prompt pump inhibitors (lansoprazole), (5)contraindication to treatment drugs, (6) pregnant or lactating women, (7) severe concurrent diseases, and (8) Patients who cannot give informed consent by himself or herself.
Key Trial Info
Start Date :
June 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2017
Estimated Enrollment :
1620 Patients enrolled
Trial Details
Trial ID
NCT01906879
Start Date
June 1 2013
End Date
December 1 2017
Last Update
June 12 2017
Active Locations (10)
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1
Chiayi Christian Hospital
Chiayi City, Taiwan
2
National Taiwan University Hospital, Hsinchu Branch
Hsinchu, Taiwan
3
E- DA Hospital and I-Shou University
Kaohsiung City, Taiwan
4
Kaohsiung Medical University Hospital
Kaohsiung City, Taiwan