Status:
UNKNOWN
Application of Remote Ischemic Preconditioning in Patients Undergoing Open Heart Surgeries
Lead Sponsor:
University of Campinas, Brazil
Conditions:
Coronary Artery Disease
Valvular Heart Disease
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Strategies for myocardial protection during open heart surgeries are desired. Several experimental studies have shown beneficial effects of remote ischemic preconditioning (RIPC). The underlying mecha...
Eligibility Criteria
Inclusion
- Patients older than 18 years
- Scheduled for coronary artery bypass grafting with or without valve replacement associated
- Use of blood cardioplegia
- EuroSCORE II greater than or equal to 1.0%
Exclusion
- History of cardiogenic shock
- Complications in the admission
- Pregnant patients
- Severe peripheral arterial disease affecting the upper limbs
- Liver failure (bilirubin ˃ 20 mmol / L, INR 2.0 ˃)
- Significant pulmonary disease (˂ FEV1 40%)
- Renal failure with glomerular filtration rate ˂ ml/min/1,73 m²
- Concomitant treatment with glibenclamide or nicorandil (medications that interfere with cardioprotection induced by IPCR)
Key Trial Info
Start Date :
August 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2015
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT01906918
Start Date
August 1 2013
End Date
August 1 2015
Last Update
November 28 2013
Active Locations (1)
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1
Hospital das Clínicas da Unicamp
Campinas, São Paulo, Brazil, 13100000