Status:
WITHDRAWN
Effects of Nicotine Replacement Therapy and D-cycloserine on Nicotine Treatment Seekers
Lead Sponsor:
New York State Psychiatric Institute
Conditions:
Cigarette Smoking
Eligibility:
All Genders
21-55 years
Phase:
PHASE2
Brief Summary
The investigators previously developed a cigarette cue extinction treatment (CET) procedure in non-treatment seeking volunteer smokers in our nicotine laboratory. The goal of Cue Extinction Treatment ...
Eligibility Criteria
Inclusion
- Seeking treatment for nicotine dependence
- Medically healthy on the basis of physical examination and medical history, vital signs, EKG, and laboratory tests, with a negative pregnancy test for females.
- A DSM-IV diagnosis of nicotine dependence with physiological dependence. Has smoked at least 15 cigarettes daily for at least two years.
- Able to perform study procedures.
- Males or females between the ages of 21-55 yrs.
- Female Participants agree to use an effective method of birth control
Exclusion
- A DSM-IV diagnosis of lifetime history of abuse or dependence on alcohol or drugs other than nicotine
- Current Axis I diagnosis or current treatment with psychotropic medications (within last three months).
- Lifetime history of schizophrenia or other psychotic disorders, bipolar disorder, or anxiety disorders.
- Participants on parole or probation
- History of significant recent violent behavior, e.g., one or more incidents of violent behavior in the past year resulting in physical damage.
- Unstable medical condition, Blood pressure \> 140/90, Pregnancy.
- History of allergic reaction to nicotine patch.
- History of hypersensitivity to cycloserine.
- Any history of seizures
- History of renal disease.
Key Trial Info
Start Date :
August 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2016
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01907594
Start Date
August 1 2013
End Date
September 1 2016
Last Update
October 8 2020
Active Locations (1)
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1
New York State Psychiatric Institute
New York, New York, United States, 10032