Status:
UNKNOWN
Muscle Metabolism and Oxygenation During Localized Fatigue-exercise in COPD
Lead Sponsor:
Laval University
Collaborating Sponsors:
Canadian Lung Association
Conditions:
Pulmonary Disease, Chronic Obstructive
Eligibility:
All Genders
50-75 years
Phase:
NA
Brief Summary
The purpose of this study is to investigate whether a localized exercise, in which cardiorespiratory demand is reduced, will result in greater limb muscle fatigue in patients with COPD as a consequenc...
Eligibility Criteria
Inclusion
- COPD (FEV1/FVC \< 0.70 and FEV1 \< 0.80 predicted
- Healthy subjects: no evidence of airways obstruction (FEV1/FVC \> 0.70 and FEV1 \> 0.80 predicted)
- Smoking history \> 15 pack-years
Exclusion
- Chronic hypoxemia and/or hypercapnia (PaO2 \< 60 mmHg or SpO2 \< 88% at rest and/or PaCO2 \> 45 mmHg)
- Recent exacerbation (\< 3 months)
- Recent cancer (\< 3 years)
- Diabetes
- Myopathy, neuromuscular or articular disease
- Unstable cardiac disease
- Absolute contraindications to exercise testing
- Regular physical activity or exercise training program in the last 2 months
- Physical activity score \> 9 in the Voorips questionnaire
- Thigh skinfold thickness \> 15 mm
- BMI \> 30
Key Trial Info
Start Date :
September 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01909544
Start Date
September 1 2011
Last Update
February 7 2014
Active Locations (1)
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1
Institut universitaire de cardiologie et de pneumologie de Québec
Québec, Quebec, Canada, G1V 4G5