Status:
COMPLETED
Reconstructing Consciousness and Cognition
Lead Sponsor:
University of Michigan
Collaborating Sponsors:
University of Pennsylvania
Washington University School of Medicine
Conditions:
Postoperative Cognitive Dysfunction
Eligibility:
All Genders
20-40 years
Phase:
NA
Brief Summary
Currently it is unknown how the human brain reorganizes its network organization to generate conscious experience and cognitive activity after a period of unconsciousness. Therefore, the purpose of th...
Eligibility Criteria
Inclusion
- Healthy 20-40 year old volunteers,
- American Society of Anesthesiologists Physical Status I or II (i.e., healthy),
- Body mass index \< 30 kg/m2,
- Easily visualized uvula,
- With anticipated equal recruitment of males and females.
Exclusion
- Physical signs suggestive of difficult airway (e.g., mouth opening \<3cm, short distance between the chin and neck, poor mandibular subluxation, thick neck),
- History of obstructive sleep apnea,
- Reactive airway disease,
- Neuropsychiatric disorders,
- History or current use of psychotropic medications,
- Current tobacco and alcohol use,
- History of hypertension or current medication for blood pressure control, cardiovascular disease or arrhythmias,
- Positive urine toxicology screen,
- History of reflux,
- Pregnancy,
- Family history of problems with anesthesia (including but not limited to malignant hyperthermia),
- Sleep disorders,
- History of postoperative nausea/vomiting or motion sickness,
- Allergy to eggs, egg products or soy.
Key Trial Info
Start Date :
July 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 9 2015
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01911195
Start Date
July 1 2013
End Date
February 9 2015
Last Update
February 20 2024
Active Locations (3)
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1
University of Michigan
Ann Arbor, Michigan, United States, 48109
2
Washington University in St. Louis
St Louis, Missouri, United States, 63110
3
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104