Status:
COMPLETED
N-PhenoGENICS: Neurocognitive-Phenome, Genome, Epigenome and Nutriome In Childhood Leukemia Survivors
Lead Sponsor:
The Hospital for Sick Children
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Canadian Cancer Society (CCS)
Conditions:
Childhood Leukemia Survivors
Eligibility:
All Genders
8-20 years
Brief Summary
To find possible therapeutic targets to help prevent long-term brain and behavioural side effects in survivors of childhood leukemia that may have been caused by chemotherapy (Treatment-Related late A...
Detailed Description
Hypothesis Genetic variants of the elements in the folate-related cycles and methotrexate disposition networks are associated with the TRANCE phenotype of childhood leukemia survivors. Objectives 1....
Eligibility Criteria
Inclusion
- Past diagnosis of acute lymphoblastic leukemia
- 8 years : 0 months - 20 years : 11 months old at the time of their study visit
- At least 2 years : 0 months from the last treatment for acute lymphoblastic leukemia at the time of their study visit
- Continuous complete remission and undergone no bone marrow transplantation or cranial radiation therapy
- Fluent in English (a subject and one parent) for test completion
- Signed informed consent
Exclusion
- Inability to complete the phenotyping tests
- Down Syndrome diagnosis
Key Trial Info
Start Date :
July 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2019
Estimated Enrollment :
204 Patients enrolled
Trial Details
Trial ID
NCT01913093
Start Date
July 1 2013
End Date
June 1 2019
Last Update
October 8 2020
Active Locations (1)
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1
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8