Status:
COMPLETED
Acarbose and Older Adults With Postprandial Hypotension
Lead Sponsor:
Kenneth Madden
Conditions:
Other Specified Hypotension
Syncope
Eligibility:
All Genders
65+ years
Phase:
PHASE2
Brief Summary
The current proposal will determine if blocking carbohydrate intake in the small intestine with Acarbose can be a possible therapy for older adults with (PPH) Post Prandial Hypotension (a drop of bloo...
Detailed Description
Blocking the absorption of carbohydrates at the brush border of the small intestine with acarbose (an alpha-glucosidase inhibitor) seems a promising possibility as a potential therapeutic agent. Altho...
Eligibility Criteria
Inclusion
- be 65 years of age or older,
- be a non-smoker for at least 5 years
- be referred to the falls clinic at Vancouver General Hospital
- have a Folstein test of cognition \> 25/30 to ensure meal log-book compliance
Exclusion
- no oral or swallowing issues that would prevent a Meal Test
- subject requiring dialysis due to end-stage renal failure will be excluded
- subjects with evidence on history, physical or blood work of hepatic disease will be excluded since elevated serum transaminases are a potential adverse effect of acarbose
- cannot currently be taking an alpha-glucosidase inhibitor
- cannot have had allergic reactions to alpha-glucosidase inhibitors in the past
- Due to the fact that acarbose is renally excreted, all subjects must have a Creatine Clearance of greater than 25 ml/min
- Subjects with a past history of inflammatory bowel disease, intestinal obstruction, ileus and peptic ulcer disease will be excluded
- Subjects taking carbohydrate-splitting enzymes (such as amylase) will be excluded
- Subjects with chronic respiratory issues requiring treatment will be excluded
Key Trial Info
Start Date :
January 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2021
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT01914133
Start Date
January 1 2014
End Date
May 1 2021
Last Update
May 28 2021
Active Locations (1)
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1
Vancouver Coastal Health Research Institute, VGH Research Pavilion Room 186
Vancouver, British Columbia, Canada, V5Z 1M9