Status:
COMPLETED
Tumor and Development (TED)
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Tumor and Abnormalities of the Development
Eligibility:
All Genders
Up to 18 years
Brief Summary
The overall project goal is to build a database of childhood cancers associated with developmental anomalies; it aims at identifying new syndromes of genetic predisposition and at enabling the further...
Detailed Description
Most of the solid cancers arising in the childhood develop from embryonic tissues. The frequent association of paediatric cancers and abnormalities of the development underlines the link between oncog...
Eligibility Criteria
Inclusion
- Inclusion Criteria :
- \- Patient who developed before the age of 18 years a solid tumour or a malignant or borderline hemopathy.
- AND
- Presenting one or several abnormality (ies) of the development provided it is not related to the treatment and\\or to the disease among:
- organ malformation, familial or not
- neuro-sensory deficit, familial or not
- delay of psychomotor acquisitions
- epilepsy (not as a sequelae of the tumour)
- disorder of growth and\\or weight and\\or of the cranial perimeter
- congenital, sporadic and\\or familial endocrine or metabolic disease
- dysmorphy
- Informed consent of patient and parents to this study OR
- tumour predisposition syndrome or developmental abnormality in a familial context, the molecular basis might have been already identified or not
- Exclusion Criteria:
- absence of malignancy in the index case
- lack of developmental anomalies in the index case or in a related first degree
- abnormal development recognized as acquired (traumatic, toxic, infectious, perinatal…)
- age \> 18 years at diagnosis of the tumor
- Lack of informed consent of the legal representatives
- The familial aggregations of cancer without developmental disease are not included in this study.
Exclusion
Key Trial Info
Start Date :
June 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2022
Estimated Enrollment :
998 Patients enrolled
Trial Details
Trial ID
NCT01915797
Start Date
June 1 2013
End Date
December 1 2022
Last Update
February 6 2023
Active Locations (1)
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1
Hôpital Necker Enfants Malades
Paris, France, 75015