Status:

COMPLETED

Pomegranate Extract Supplementation in Colorectal Cancer Patients

Lead Sponsor:

National Research Council, Spain

Collaborating Sponsors:

Hospital Universitario Reina Sofia de Cordoba

Conditions:

Colorectal Cancer

Eligibility:

All Genders

18+ years

Phase:

PHASE1

PHASE2

Brief Summary

The most relevant pomegranate phenolics (ellagitannins and ellagic acid) are extensively metabolized by the human gut microbiota to yield a number of metabolites called urolithins (mainly Uro-A). Urol...

Eligibility Criteria

Inclusion

  • Colorectal cancer diagnosis.
  • Surgery required.
  • WHO status: between 0 and 2.
  • Hemoglobin \>10 g/dL
  • ALT \>2.5-fold above the normal value.
  • Serum Bilirubin \>1.5-fold above the normal value.
  • Creatinine \<140 micromol/L

Exclusion

  • Patients who do not satisfy inclusion criteria and,
  • Active pectic ulcer.
  • Pregnancy or breastfeeding.
  • Alcoholism.
  • Chemotherapy or radiotherapy a month prior to recruitment.
  • Treatment with steroids or other anti-inflammatory drugs a week prior to recruitment.

Key Trial Info

Start Date :

June 1 2012

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

April 1 2015

Estimated Enrollment :

60 Patients enrolled

Trial Details

Trial ID

NCT01916239

Start Date

June 1 2012

End Date

April 1 2015

Last Update

April 14 2015

Active Locations (1)

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1

Hospital General Universitario Reina Sofía

Murcia, Murcia, Spain, 30003