Status:
UNKNOWN
VEGF Signaling Promotes Cell Growth and Metastasis in Intrahepatic Cholangiocarcinoma in a VEGF Receptor Mediated Pathway
Lead Sponsor:
First Affiliated Hospital, Sun Yat-Sen University
Collaborating Sponsors:
Guangdong Province, Department of Science and Technology
Conditions:
Intrahepatic Cholangiocarcinoma
Eligibility:
All Genders
16-90 years
Brief Summary
The investigators study the VEGF signaling in ICC cell lines／human tissues and its mechanism in HCC growth, proliferation and apoptosis.
Detailed Description
Several studies have documented the elevated expression of VEGF and its receptors in ICC cell lines and tumor tissues. Another study observed that the elevation of VEGF promotes the growth. Clinical a...
Eligibility Criteria
Inclusion
- hepatocellular patients diagnosed through biopsy;or either dynamic imagine with a diagnosis of intrahepatic cholangiocarcinoma and CA199\>100U/L；or two or more dynamic imagine with a diagnosis of intrahepatic cholangiocarcinoma
- Child-Pugh A or B
- well preserved renal and hematopoietic Function
- receive complete surgical therapy
- achieve complete section accessed by contrast-enhanced CT
Exclusion
- incomplete section
- Child-Pugh C
- combination with other hepatobiliary disease
- suffer from other tumors concurrently or in last five years
Key Trial Info
Start Date :
October 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2014
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01917370
Start Date
October 1 2012
End Date
December 1 2014
Last Update
August 6 2013
Active Locations (1)
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1
First Affiliated Hospital, Sun Yat-Sen University
Guangzhou, Guangdong, China, 510000