Status:
UNKNOWN
Increased Activity of a Renal Salt Transporter (ENaC) in Diabetic Kidney Disease
Lead Sponsor:
University of Southern Denmark
Collaborating Sponsors:
Odense University Hospital
Region of Southern Denmark
Conditions:
Diabetic Nephropathies
Hypertension
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
The purpose of the study is to determine whether a diuretic drug called amiloride is capable of increasing renal salt excretion and thereby decrease blood pressure in diabetic patients with kidney dis...
Eligibility Criteria
Inclusion
- Type 1 diabetes
- Negative pregnancy test at inclusion and taking contraceptive medication
- One group with diabetic nephropathy and overt proteinuria
- One normoalbuminuric group without nephropathy
- Creatinine clearance \> 40 ml/min
Exclusion
- Type 2 diabetes
- Receiving amiloride, glucocorticoids, aldosterone or spironolactone
- Clinically relevant organic or systemic disease including malignancy
Key Trial Info
Start Date :
October 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT01918488
Start Date
October 1 2013
Last Update
October 16 2013
Active Locations (1)
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1
Cardiovascular and Renal Research
Odense, Denmark, DK-5000