Status:
COMPLETED
Loaded and Unloaded Magnetic Resonance (MR) Imaging of Meniscus-Cartilage-Trabecular Bone in Osteoarthritis
Lead Sponsor:
University of California, San Francisco
Conditions:
Knee Osteoarthritis
Eligibility:
All Genders
35-80 years
Phase:
NA
Brief Summary
The objective of this project is to determine the effects of gait-retraining on articular cartilage composition, gait mechanics, pain and function in persons with mild to moderate knee osteoarthritis ...
Detailed Description
Variables of gait mechanics during walking have been linked to the onset and progression of knee osteoarthritis (OA). The knee adduction moment is one key variable that has been identified as an impor...
Eligibility Criteria
Inclusion
- Men and women
- At least 35 years of age
- Mild OA patients with arthritic knee symptoms and KL score of 1-2
- Severe OA patients with arthritic knee symptoms and KL score of 3-4
- Knee symptoms in OA patients is defined as pain, aching, or stiffness on most days of a month during the past year or use of medication for treatment of knee pain on most days of a month during the past year
- self reported knee pain (defined as medial compartment knee pain at least 1 day per week during each of the 6 weeks prior to participation) and at least 3 of the following 6 clinical indicators: Age\>50 years; morning stiffness\<30 minutes duration; crepitus on active motion; tenderness of the bony margins of the knee joint; bony enlargement at the knee; and lack of palpable warmth of the synovium
Exclusion
- current use of investigational drug
- conditions other than OA which limit lower extremity function and mobility and/or would confound the evaluation of function (e.g., clinically significant spinal disc degeneration, painful or dysfunctional feet, peripheral vascular disease, lumbar radiculopathy, trochanteric bursitis, hip pain, lumbar pain)
- Patients with metallic fragments in the eyes, vascular clips, pacemakers, and other contraindications to MRI
- History of joint replacement, intra-articular fracture, osteotomy, arthroplasty or meniscectomy of the signal knee
- History of other disease that may involve the study joint including systemic inflammatory disease, crystalline disease, knee infection of the signal knee, avascular necrosis, Paget's disease or tumors
- Self reported heart condition that limits any daily physical activity
- Patients who are pregnant
Key Trial Info
Start Date :
September 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2016
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT01919736
Start Date
September 1 2013
End Date
December 1 2016
Last Update
November 18 2019
Active Locations (1)
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1
China Basin Imaging Center
San Francisco, California, United States, 94107