Status:
COMPLETED
Nebivolol, Lifestyle Modification and Arterial Stiffness
Lead Sponsor:
Virginia Polytechnic Institute and State University
Collaborating Sponsors:
Forest Laboratories
Conditions:
Hypertension
Eligibility:
All Genders
40-75 years
Phase:
PHASE4
Brief Summary
Numerous anti-hypertensive drugs have been reported to be efficacious in reducing central arterial stiffness and these effects may contribute to improved outcomes in hypertensive patients. However, th...
Eligibility Criteria
Inclusion
- Stage 1 hypertension
- 40-75 years
- Weight stable (+/-2 kg)
- Sedentary to recreationally active
- Willing to be randomized to one of three arms
- Verbal and written consent
- Approval by medical director
Exclusion
- Blood pressure outside stated range
- Diabetes or taking diabetes medications
- Total cholesterol \>6.2 mmol/L; triglycerides \>4.5 mmol/L
- Past or current ischemic heart disease, stroke, respiratory disease, endocrine or metabolic disease, neurological disease, or hematological-oncological disease
- Medications (including but not limited to antihypertensives, statins or other with anti-inflammatory actions) or antioxidant vitamins or supplements
- Known allergy or hypersensitivity to nebivolol or any of its components
- Inability to perform regular physical activity or participate in other components of lifestyle modification
- Pregnant or planning to become pregnant
Key Trial Info
Start Date :
January 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2012
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT01920282
Start Date
January 1 2010
End Date
August 1 2012
Last Update
February 23 2018
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