Status:
COMPLETED
Blame Rebalance fMRI Feedback Proof-of-concept
Lead Sponsor:
D'Or Institute for Research and Education
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The investigators have shown that decoupling of brain networks when feeling guilty is the first potential functional neuroimaging biomarker of risk of major depression. It remains detectable on remiss...
Detailed Description
Specific aim 1: Demonstrate that anterior temporal lobe (ATL)-septal/subgenual cingulate (SCSR) coupling for guilt can be increased through one session of neurofeedback in the group seeing visual feed...
Eligibility Criteria
Inclusion
- past major depressive episode according to Diagnostic Statistical Manual (DSMIV) for at least 2 months, currently not fulfilling criteria for depression and remitted from symptoms for at least 2 months
Exclusion
- suicidal thoughts
- other current DSM-IV axis-I disorders
- a history of atypical major depressive episodes (DSM-IV)
- Global Assessment of Functioning scores below 80 as a sign of incomplete remission or co-morbidity
- \>2 points on the suicidality item of the Hamilton Depression Scale
- prior criminal convictions
- history of violent behavior towards persons as determined by clinical interview
- positive past or current screening question for irritability on the mood disorders module
- antisocial personality as determined on personality interview using DSM-IV criteria
- borderline personality disorder as determined on personality interview using DSM-IV criteria according to the personality interview
- current self-harming behaviors
Key Trial Info
Start Date :
May 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2014
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT01920490
Start Date
May 1 2013
End Date
October 1 2014
Last Update
July 23 2015
Active Locations (1)
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1
Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro
Rio de Janeiro, Rio de Janeiro, Brazil, 22290-140