Status:
ACTIVE_NOT_RECRUITING
Correlation of the Arrhythmia Mechanism and Substrate to Ablate Persistent Atrial Fibrillation Study
Lead Sponsor:
Ottawa Heart Institute Research Corporation
Conditions:
Persistent Atrial Fibrillation
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
This is a pilot study to assess the usefulness of ECG mapping, and enhanced MRI and PET scan imaging in identifying atrial fibrosis and arrhythmia circuits involved in persistent atrial fibrillation a...
Detailed Description
Pulmonary vein isolation catheter ablation for the treatment of persistent AF (PeAF)or longstanding persistent AF is associated with success rates of 40-50% at one year. Experimental models have shown...
Eligibility Criteria
Inclusion
- Age ≥18 years and ≤ 80 years;
- Symptomatic persistent AF AND clinically indicated for AF catheter ablation
- At least one episode of AF lasting more than 7 days, documented on 12-lead ECG, Holter monitor, 2-week loop monitor or trans-telephonic monitor (TTM) within 12 months of enrollment in the study
- Able to provide informed consent.
Exclusion
- History of previous catheter or surgical ablation for AF
- Presence of intracardiac thrombus
- contraindication to systemic oral anticoagulation therapy
- Subjects with reversible causes of AF
- Antero-posterior left atrial dimension \> 60 mm on echocardiography
- Severe valvular disease (mitral/aortic stenosis or regurgitation);
- Subjects that are pregnant or breastfeeding;
- Chronic kidney disease and creatinine clearance \<50ml/min.
- Contraindication to MRI Imaging (e.g. permanent pacemaker, metallic implants, etc)
Key Trial Info
Start Date :
September 14 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 31 2026
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT02184013
Start Date
September 14 2015
End Date
January 31 2026
Last Update
August 15 2025
Active Locations (1)
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1
University of Ottawa Heart Institute
Ottawa, Ontario, Canada, K1Y 4W7