Status:
UNKNOWN
Induction Chemotherapy Followed By Chrono-chemotherapy Concurrent With IMRT Of Locally Advanced NPC Clinical Study
Lead Sponsor:
Feng Jing
Conditions:
Nasopharyngeal Carcinoma
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
Brief Summary
Comparing induction chemotherapy followed by cisplatin chrono-chemotherapy concurrent combined with intensity-modulated radiation therapy (chrono-chemotherapy group) with induction chemotherapy follow...
Eligibility Criteria
Inclusion
- Pathological diagnosis of early cure Ⅲ - Ⅳ stage of patients with advanced nasopharyngeal carcinoma (according to the 2010 UICC staging criteria, T3-4, N0-3), no evidence of distant metastasis (M0). A measurable tumor lesions;
- Karnofsky score≥70;
- Age 18-70 years old, male or female;
- No major organ dysfunction; Normal bone marrow hematopoietic function (white blood cell ≥4．0×109／L，platelet≥100×109 /L. hemoglobin ≥100g/L)，normal liver function (total bilirubin、alanine aminotransferase、 aspartate aminotransferase ≤1.5 times the upper limit of normal)，normal renal function (creatinine ≤1.5 times the upper limit of normal) electrocardiogram does not affect the normal treatment;
- To understand this study and sign informed consent form.
Exclusion
- A distant metastasis;
- Patients with physical or mental illness, and researchers think that patients can't fully or adequately understand the possible complications of this study;
- Pregnancy (confirmed by serum or urine β-HCG test) or between lactation period;
- Serious complications, such as uncontrollable hypertension, heart function failure, diabetes, etc.; 5.Who had received radiation and chemotherapy.
Key Trial Info
Start Date :
May 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2019
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT02187315
Start Date
May 1 2014
End Date
December 1 2019
Last Update
July 11 2014
Active Locations (1)
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1
The Affiliated Hospital of Guiyang Medical College/The Affiliated Cancer Hospital of Guiyang Medical College/Guizhou Cancer Hospital
Guiyang, Guizhou, China, 550001