Status:
COMPLETED
Pharmacokinetics of BIBR 277 in Hypertensive Patients
Lead Sponsor:
Boehringer Ingelheim
Conditions:
Hypertension
Eligibility:
All Genders
20+ years
Phase:
PHASE2
Brief Summary
The pharmacokinetic profile of BIBR 277 single dose given in capsule form to hypertensives was evaluated. The results of the present study are to be used in the Japanese population pharmacokinetics an...
Eligibility Criteria
Inclusion
- Age: \>=20 years
- Sex: Either male or female
- Patient status: Either inpatient or outpatient, provided that the patient was available for hospitalisation from the day before the trial medication administration until the morning of the day after administration
- BP: Sitting systolic and diastolic blood pressures (SBP and DBP) taken the day before administration should be \>= 150 mmHg and \>= 90 mmHg, respectively. Patients undergoing treatment with other antihypertensives were not excluded provided the above criteria were satisfied.
Exclusion
- Malignant hypertension
- Renovascular hypertension
- Severe heart failure (NYHA functional class III - IV), unstable angina pectoris, or history of myocardial infarction (within 6 months of onset)
- Atrioventricular conduction disturbance (degree II to III), atrial fibrillation, or serious arrhythmia
- Symptoms of cerebrovascular disorder
- Serious hepatic dysfunction
- Renal function disorder (serum creatinine \>= 4.0 mg/dL)
- Known hypersensitivity to angiotensin II receptor antagonists
- Hyperkalaemia (potassium \>= 5.5 milliequivalents per liter (mEq/L))
- Treatment with the other investigational drug within 6 months of initiation of the present study
- Pregnant, breast feeding, possibly pregnant or planning to become pregnant during this study
- Previous treatment with the trial medication of the present study
- Otherwise judged ineligible by the investigator
Key Trial Info
Start Date :
June 1 1998
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
93 Patients enrolled
Trial Details
Trial ID
NCT02187497
Start Date
June 1 1998
Last Update
July 11 2014
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