Status:
COMPLETED
Pentriox - Induction of Oxidative Stress
Lead Sponsor:
Henrik Enghusen Poulsen
Collaborating Sponsors:
Klinisk Biokemisk Afdeling
Klinisk farmakologisk Afdeling
Conditions:
Oxidative Stress
Eligibility:
MALE
18-35 years
Phase:
PHASE1
Brief Summary
The purpose of the study is to investigate phenoxymethylpenicillin (the v-penicillin) and trimethoprim's possible induction of oxidative stress in human cells. The induction is examined by comparing c...
Eligibility Criteria
Inclusion
- Caucasian
- healthy men
- non-smoker
- 18-35 years
- BMI: 18-30
Exclusion
- Smoker
- high blood pressure
- allergies towards any of the tested medicine
- galactose-intolerance
- abnormal lipid profile
- CRP \> 10
- Glucose/galactose-malabsorption
- Use of medications and herbal remedies that affect/are affected by v-penicillin and trimethoprim
- intake of narcotics 2 months prior to trial
- intake of supplements 1 month prior to trial
- bronchial asthma
- allergies
- heart deficiencies
- brady cardia
- kidney disease
- liver disease
- hypo-potassium
- phenylketonuria
Key Trial Info
Start Date :
November 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2011
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT02188472
Start Date
November 1 2010
End Date
February 1 2011
Last Update
July 11 2014
Active Locations (1)
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1
Department of Clinical Pharmacology
Copenhagen, Denmark, 2100