Status:
COMPLETED
Genetic Susceptibility to Rheumatic Heart Disease in the Pacific Region
Lead Sponsor:
University of Oxford
Collaborating Sponsors:
Ministry of Health, Fiji
Fiji National University
Conditions:
Rheumatic Heart Disease
Mitral Stenosis
Eligibility:
All Genders
5+ years
Brief Summary
The purpose of this study is to investigate whether there are genetic differences between patients with rheumatic heart disease and members of the general population.
Detailed Description
The investigators will micro-array genotype approximately 300,000 single nucleotide polymorphisms (SNP) using DNA samples from patients with rheumatic heart disease (cases) from New Caledonia and Fiji...
Eligibility Criteria
Inclusion
- Cases
- Diagnosis of rheumatic heart disease based on one of:
- World Heart Federation definite echocardiographic criteria
- World Heart Federation borderline echocardiographic criteria and history of acute rheumatic fever
- Mitral stenosis with valve area less than 2.0 cm2
- Previous surgery for rheumatic heart disease
Exclusion
- Age less than five years
- Inability to give consent
- New Controls
- Inclusion criteria:
- Healthy individual living in a community where cases were identified
Key Trial Info
Start Date :
September 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
2372 Patients enrolled
Trial Details
Trial ID
NCT02188862
Start Date
September 1 2012
End Date
December 1 2013
Last Update
July 15 2014
Active Locations (3)
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1
Colonial War Memorial Hospital
Suva, Fiji
2
Centre Hospitalier Territorial de Nouvelle Caledonie
Noumea, New Caledonia
3
Wellcome Trust Centre for Human Genetics, University of Oxford
Oxford, United Kingdom, OX3 7BN