Status:
COMPLETED
Endogenous Opioid Mechanisms for Rejection Sensitivity
Lead Sponsor:
Stony Brook University
Collaborating Sponsors:
University of Michigan
National Institute of Mental Health (NIMH)
Conditions:
Rejection Sensitivity
Eligibility:
All Genders
18-25 years
Brief Summary
This project hypothesizes that the brain's opioid system determines rejection sensitivity, a personality trait that is a vulnerability factor and feature of several psychiatric disorders. This project...
Detailed Description
Humans depend on acceptance into groups and intimate relationships for survival and emotional well-being. Actual or perceived threats to this need such as social rejection (when one is not wanted or l...
Eligibility Criteria
Inclusion
- Men and women age 18-25 (inclusive)
- Right-handed
- Native English speaker
- Not currently in a romantic relationship
- Willing and able to participate in a PET scan
Exclusion
- Not on hormonal birth control
- Not pregnant
- Consume less than 5 cigarettes per week and less than 14 alcoholic drinks per week, on average
- No use of recreational or street drugs in the past two years (e.g. marijuana)
- Willing to abstain from alcohol and/or tobacco for 48 hours
- No major untreated medical problems
- Never diagnosed with a psychiatric or neurological disorder
- Potential problems with having an MRI scan (claustrophobia, metal objects, etc.)
Key Trial Info
Start Date :
August 1 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 6 2019
Estimated Enrollment :
114 Patients enrolled
Trial Details
Trial ID
NCT02189785
Start Date
August 1 2016
End Date
June 6 2019
Last Update
October 22 2020
Active Locations (1)
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1
University of Michigan
Ann Arbor, Michigan, United States, 48109