Status:
UNKNOWN
Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions
Lead Sponsor:
West China Hospital
Conditions:
Pituitary Neoplasms
Craniopharyngiomas
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of this four-arm randomized controlled study is to determine whether eliminating glucocorticoids (GC) replacement in perioperative period in surgical patients with sellar lesion could resu...
Eligibility Criteria
Inclusion
- Age \>= 18
- Surgical patients with MRI-confirmed diagnosis of sellar lesions (non-functioning pituitary adenoma or craniopharyngioma)
Exclusion
- Patients with pre-existing hyperthyroidism or Cushing's syndrome
- Patients with long-term glucocorticoids replacement history
- Patients with other co-morbidities that pose known influence upon the HPA-axis function (cardiovascular or cerebrovascular disease, metabolic disease or epilepsy)
- Patients with severe panhypopituitarism
- Patients with history of radiotherapy of the pituitary gland
Key Trial Info
Start Date :
August 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2014
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT02190994
Start Date
August 1 2013
End Date
December 1 2014
Last Update
July 15 2014
Active Locations (1)
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1
West China Hospital, Sichuan University
Chengdu, Sichuan, China, 610041