Status:
COMPLETED
Dietary Intervention Replacing Carbohydrate With Protein and Fat Has Greater Effect on Peripheral Blood Mononuclear Cell Metabolites Than on Plasma Metabolites in Patients With Prediabetes or Type-2 Diabetes
Lead Sponsor:
Yonsei University
Conditions:
Prediabetes
Type-2 Diabetes
Eligibility:
All Genders
40-70 years
Phase:
PHASE2
Brief Summary
This study examined whether dietary-induced reductions in lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in peripheral blood mononuclear cells (PBMC) and plasma affected metabolic profiles...
Detailed Description
Eighty nonobese patients (aged 40-70 years) with prediabetes or newly diagnosed type-2 diabetes were randomly assigned to a control group (normal diet with refined rice) or a whole-grain group (replac...
Eligibility Criteria
Inclusion
- subjects who had IFG (100≤ fasting glucose \<126 mg/dL)
- or newly diagnosed type-2 diabetes (fasting glucose ≥126 mg/dL)
Exclusion
- current and/or past history of cardiovascular disease including angina
- liver or kidney dysfunction
- thyroid or pituitary disease
- pregnancy or lactation
- taking medications or supplements
Key Trial Info
Start Date :
January 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2013
Estimated Enrollment :
82 Patients enrolled
Trial Details
Trial ID
NCT02191644
Start Date
January 1 2013
End Date
June 1 2013
Last Update
July 16 2014
Active Locations (1)
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1
Yonsei University
Seoul, South Korea, 120-749