Status:
TERMINATED
A Study of LY2951742 in Participants With Mild to Moderate Osteoarthritis Knee Pain
Lead Sponsor:
Eli Lilly and Company
Conditions:
Osteoarthritis, Knee
Eligibility:
All Genders
40-75 years
Phase:
PHASE2
Brief Summary
The main purpose of this study is to test if LY2951742 relieves mild to moderate knee pain. The study drugs will be given as an injection under the skin and as an oral capsule. The study will last abo...
Eligibility Criteria
Inclusion
- Have osteoarthritis (OA) of the knee joint based on American College of Rheumatology (ACR) criteria and confirmed with X-rays and ACR functional class of I to III
- Have been on stable dose of prescription Nonsteroidal Anti-Inflammatory Drugs (NSAIDS), celecoxib, tramadol, or acetaminophen of at least 2000 mg per day for at least 20 days in the past month
- Willing to stop all analgesics for OA pain during the study
- Experienced pain while walking in the target knee of 50-90 mm inclusive on 0-100 Visual Analog Scale (VAS) with an increase in pain while walking of at least 10 mm following washout of current Osteoarthritis pain medications at screening
Exclusion
- Allergic to LY2951742, celecoxib, other NSAIDS, including aspirin, and similar drugs
- Arthritis of the knee from other causes
- Uncontrolled hypertension
- Have OA pain that requires treatment with potent opioids, systemic corticosteroids, intra-articular injections, duloxetine, or venlafaxine
- Moderate to severe renal impairment
- Pregnant or lactating
Key Trial Info
Start Date :
July 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2015
Estimated Enrollment :
268 Patients enrolled
Trial Details
Trial ID
NCT02192190
Start Date
July 1 2014
End Date
June 1 2015
Last Update
September 10 2019
Active Locations (38)
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1
Achieve Clinical Research, LLC
Birmingham, Alabama, United States, 35216
2
Dream Team Clinical Research
Anaheim, California, United States, 92801
3
Artemis Institute for Clinical Research
San Diego, California, United States, 92103
4
Empire Clinical Research
Upland, California, United States, 91786