Status:
COMPLETED
Dietary Methionine and Cysteine Restriction in Healthy Adults
Lead Sponsor:
Milton S. Hershey Medical Center
Collaborating Sponsors:
Orentreich Foundation for the Advancement of Science, Inc.
Conditions:
Healthy
Eligibility:
All Genders
24-65 years
Phase:
NA
Brief Summary
Studies in laboratory models indicate that dietary methionine restriction (MR) enhances longevity and produces short- and long-term metabolic changes that are consistent with a healthy lifespan. The p...
Detailed Description
In this controlled feeding study, subjects will be randomized to one of two experimental. Group A (N=10): will start with control diet (31 mg/kg/day Met; 31 mg/kg/day Cys) for 4 weeks followed by a wa...
Eligibility Criteria
Inclusion
- Healthy English speaking male and female volunteers
- May or may not be students
- Age range 24-65 years
- Subjects will need to be of normal weight or moderately overweight (BMI 18.5-35 kg/m2)
- Subjects will be non-smokers
Exclusion
- No use of medications known to impact the biomarkers of interest
- Pregnancy and lactating women
- Persons with documented diabetes
- No use of high dose dietary antioxidant supplements or fish oil/flax seed oil for n-acetylcysteine for at least 1 month prior to the study
- Use of tobacco products over the past 6 months
- Unstable weight
- Individuals with allergies to eggs, wheat, nuts, soy and latex
- Individuals with phenylketonuria (PKU)
Key Trial Info
Start Date :
July 16 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2017
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT02192437
Start Date
July 16 2014
End Date
July 1 2017
Last Update
September 7 2020
Active Locations (1)
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1
Penn State University
State College, Pennsylvania, United States, 16802