Status:
COMPLETED
Chronic Alcohol, Stress Inflammatory Response and Relapse Risk
Lead Sponsor:
Yale University
Conditions:
Alcohol Dependence
Depressive Symptomatology
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
The purpose of this study is to examine potential stress and immune systems adaptations underlying craving and relapse vulnerability in alcohol dependent (AD) individuals and social drinkers (SDs) wit...
Eligibility Criteria
Inclusion
- ADs: Male and females, aged 18-50 years, meeting current DSM-IV criteria for alcohol dependence consuming more than 25 drinks / week.
- SDs: Male and females, aged 18-50 years. Must not meet either current or lifetime DSM-IV criteria for alcohol/drug abuse. They must have demonstrated weekly alcohol use over the past year but no more than 25 drinks / month with no occasion of binge drinking (5 or more drinks-men; 4 or more -women).
- ADs and SDs must self-report depression ratings at levels to match one of the two following groups: a) a score of 20 or above in the Center for Epidemiologic Studies - Depression Scale (CES-D), or b) a score between 3 -20 on the CES-D
- Weekly alcohol use as documented by positive urine toxicology screens (AD only).
- Good health as verified by screening examinations and medical and screening
- Able to read English and complete study evaluations.
- All participants must voluntarily provide informed consent and sign the informed consent document.
Exclusion
- Meeting current criteria for dependence on another psychoactive substance, excluding nicotine.
- Having any current Axis I psychiatric disorders and requiring treatment/medication for these conditions.
- Having significant underlying medical conditions requiring medication.
- Women who are pregnant or nursing.
Key Trial Info
Start Date :
September 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2015
Estimated Enrollment :
116 Patients enrolled
Trial Details
Trial ID
NCT02193204
Start Date
September 1 2011
End Date
July 1 2015
Last Update
March 6 2020
Active Locations (1)
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1
CT Mental Health Center
New Haven, Connecticut, United States, 06519