Status:
COMPLETED
The Effects of Minocycline in Humans
Lead Sponsor:
Yale University
Conditions:
Memory Impairment
Eligibility:
All Genders
21-50 years
Phase:
PHASE1
Brief Summary
To determine minocycline's effects on cognitive performance and measures of mood in abstinent cocaine users. Minocycline is a tetracycline derivative antibiotic that also inhibits microglia activation...
Detailed Description
We are proposing a randomized, double-blind, crossover study. A total of 40 male and or female subject completers will have two 4-day treatment periods, in which they will be randomized to minocycline...
Eligibility Criteria
Inclusion
- Male and females, between the ages of 21 and 50 who fulfill criteria for past cocaine dependence according to DSM-IV criteria;
- No cocaine use for the past 30 days;
- No other current dependence or abuse of other drugs of abuse or alcohol (except cocaine and tobacco);
- No current medical problems and normal ECG;
- For women, not pregnant as determined by pregnancy screening nor breast feeding, and using acceptable birth control methods.
Exclusion
- current major psychiatric illnesses including mood, psychotic, or anxiety disorders;
- history of major medical illnesses; including liver diseases, heart disease, or other medical conditions that the physician investigator deems contraindicated for the subject to be in the study
- Current use of over-the-counter or prescription psychoactive drugs (antidepressant, anxiolytics, antipsychotics, mood stabilizers, psychostimulants) or drugs that would be expected to have major interactions with drugs to be tested, e.g., benzodiazepines, codeine, percocet, and other opiate drugs that will interact with methadone.
- Liver function tests (ALT or AST) greater than 3 times normal.
- Allergy to minocycline or other tetracyclines.
Key Trial Info
Start Date :
July 8 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 5 2015
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT02193269
Start Date
July 8 2013
End Date
November 5 2015
Last Update
September 19 2019
Active Locations (1)
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1
Veteran Affairs Hospital
West Haven, Connecticut, United States, 06516