Status:
COMPLETED
Effects of Nitrate on Liver Perfusion and Sugar Control
Lead Sponsor:
University of Exeter
Collaborating Sponsors:
Royal Devon and Exeter NHS Foundation Trust
Conditions:
Type 2 Diabetes
Ageing
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Rationale: Mediterranean style diets and diets rich in green leafy vegetables protect against the risk of developing type 2 diabetes and a wide range of cardiovascular disease. These diets are rich i...
Detailed Description
Hypothesis Inorganic nitrate from the diet, following conversion to nitrite and nitric oxide via the pathways described above will: 1. Increase hepatic microvascular perfusion 2. Increase GLP-1 secr...
Eligibility Criteria
Inclusion
- 1\. Type 2 Diabetes group; aged between 35 - 75. Able to give informed consent 2. Older adults group; aged between 50 - 75. Not on any regular vasoactive medication and able to give informed consent. 3. Young adults group; aged between18 - 35. Not on any regular vasoactive medication and able to give informed consent.
Exclusion
- • Antibiotic therapy within the preceding two weeks
- Anyone on GLP-1 analogues or DPP4 inhibitors
- Myocardial infarction or cerebro-vascular event within the preceding three months
- Current smoker (any smoking event in last 3 months)
- Previous brain surgery, cardiac pacemaker.
- Metal fragments in the eye from previous injury
- Severe claustrophobia
- Uncontrolled hypertension
- On regular organic nitrates, thiazolidinidiones or nicorandil
- eGFR \< 30
- Any other serious medical condition which would interfere with data interpretation or safety.
Key Trial Info
Start Date :
July 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 20 2017
Estimated Enrollment :
31 Patients enrolled
Trial Details
Trial ID
NCT02195856
Start Date
July 1 2014
End Date
July 20 2017
Last Update
March 19 2019
Active Locations (2)
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1
Exeter Magnetic Resonance Research Centre, St Luke's Campus
Exeter, Devon, United Kingdom, EX1 2LU
2
NIHR Exeter Clinical Research Facility
Exeter, Devon, United Kingdom, EX2 5DW