Status:
UNKNOWN
Amyloïd Load in Elderly Population: Effect of Cognitive Reserve
Lead Sponsor:
University Hospital, Bordeaux
Collaborating Sponsors:
Fondation Plan Alzheimer
General Electric
Conditions:
Plaque, Amyloid
Cognitive Deficits
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
This research aim to explore relationships between the presence of amyloid burden and cognitive performance, and its modulation by educational level. For this purpose we will combine Positron emission...
Detailed Description
Influence of educational level on the relationship between disease-specific lesion development and cognitive function will be assessed, as measured by amyloid PET imaging and a battery of neuropsychol...
Eligibility Criteria
Inclusion
- Participation in the AMI or 3C cohorts Group 1- Controls
- MMSE \> 24 or \> 26 for low and high levels of education, respectively.
- Without memory impairment (for episodic memory) on the Free and Cued Selective Reminding Test RL/RI-16 items (FCSRT), free recall \> 22 and total recall \>42, according to the thresholds for population-based studies
- Without memory complaint
- Without dementia Group 2- Cognitively-impaired subjects without dementia and without memory complaints
- Mini Mental State Evaluation (MMSE) \< 24 or \< 26 for low and high levels of education, respectively
- With memory impairments according to the RL/RI-16 test (free recall≤22 and/or total recall ≤42), according to the thresholds for population-based studies defined by Auriacombe et al., 2010.
- Without memory complaint
- Without dementia Group 3- Cognitively-impaired subjects without dementia and with memory complaints
- MMSE \< 24 or \< 26 for low and high levels of education, respectively
- With memory impairments according to the RL/RI-16 test (same thresholds as above)
- With memory complaint
- Without dementia
Exclusion
- Being left handed
- Presence of dementia (based on the clinical diagnosis)
- Presence of stroke
- Presence of Parkinson's disease
- Presence of a counter-indication for MRI
- Presence of a counter-indication for PET Scan with \[18F\]-Flutemetamol
- Presence of any health problem preventing travel to the imaging service of the University Hospital
- Being under the legal guardianship of another person or being unable to provide consent to participate
- Pregnant or breastfeeding woman
Key Trial Info
Start Date :
July 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2016
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT02196116
Start Date
July 1 2014
End Date
July 1 2016
Last Update
February 12 2015
Active Locations (1)
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1
CHU de Bordeaux
Bordeaux, France, 33000