Status:
TERMINATED
Anesthesia and Functional Connectivity: An Analysis of fMRI Changes
Lead Sponsor:
University of Michigan
Conditions:
Changes in Brain Network Connectivity
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Functional connectivity is defined as a correlation in neural activity between distinct regions of the brain. Several recent studies have demonstrated areas of low-frequency functional connectivity in...
Detailed Description
Background: A phencyclidine derivative developed by Parke-Davis represented an attempt to mimic phencyclidine anesthesia without inducing the severe psychomimetic reactions of its parent compound. In...
Eligibility Criteria
Inclusion
- Control Group:
- (4) Ability to tolerate small, enclosed spaces without anxiety; (6) English fluency.
Exclusion
- Pregnant or trying to become pregnant.
- history of serious head injury;
- possibility of ferrous metals within the body, e. g. aneurysm clips, retained particles; or metal that would impair the magnetic resonance (MR) signal, e.g., some dental hardware;
- Smoking usage \> 10 cigarettes per day
- Daily intake of caffeine exceeds 2 cups of coffee per day
- Unstable cardiac problems (e.g. severe or poorly treated hypertension, unstable arrhythmia, etc.) or concurrent medications for which anesthesia would be contraindicated
- Patients with a current general medical illness that is life threatening or inadequately treated will be excluded: moderate-to-severe chronic pain, evidence of fracture or malignancy, inflammatory joint disease, severe physical impairment (e.g., bilateral amputation, blindness), morbid obesity, autoimmune/inflammatory diseases, cardiopulmonary disorders (i.e., angina, congestive heart failure, COPD), chronic renal insufficiency, uncontrolled endocrine or allergic disorders (i.e., hyper-/hypothyroidism, diabetes, allergic rhinitis), malignancy.
- Taking any medication, prescription or non-prescription, with psychotropic effects.
- History of psychiatric or neurological illness; History of substance abuse or dependence Positive urine toxicology screen.
- Refractory Depression Group:
- Meets all above control group screening criteria except history of psychiatric illness and prescription medication usage
- Included subjects will have a Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV) diagnosis of major depressive disorder, recurrent or chronic, moderate-to-severe, without psychotic features, with medication resistance, accepted with agreement by two different psychiatrists. For this study, treatment resistance is defined as ≥2 failed adequate antidepressant trials.
- Patients with a DSM-IV diagnosis of bipolar disorder, schizophrenia, or schizoaffective disorder will be excluded. Any history of antidepressant- or substance- induced hypomania or mania will be excluded.
- Subjects will be free of comorbid substance abuse or dependence for at least 3 months, with a negative urine toxicology screen.
- No current suicide plan or intent.
- Comorbid Axis I anxiety disorder diagnoses will be permitted if they do not require current treatment.
Key Trial Info
Start Date :
February 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2015
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT02196259
Start Date
February 1 2008
End Date
May 1 2015
Last Update
May 2 2017
Active Locations (1)
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1
University of Michigan - fMRI Laboratory
Ann Arbor, Michigan, United States, 48109