Status:
COMPLETED
Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing
Lead Sponsor:
University of Geneva, Switzerland
Conditions:
Chronic Periodontitis
Eligibility:
All Genders
25-70 years
Phase:
PHASE4
Brief Summary
It is common practice to carry out the therapy of periodontal diseases in two phases. In a first, non-surgical phase, bacterial deposits on tooth surfaces (plaque and calculus) are removed using a cle...
Detailed Description
Single center, randomized placebo controlled crossover clinical trial with a one-year follow-up. Eighty participants with Aggregatibacter actinomycetemcomitans-associated chronic or aggressive periodo...
Eligibility Criteria
Inclusion
- Untreated moderate to advanced periodontitis (at least 4 teeth with a probing pocket depth (PD) \>4 mm, clinical attachment loss of at least 2 mm and radiographic evidence of bone loss)
- Presence of at least 12 scorable teeth (not including 3rd molars, teeth with orthodontic appliances, bridges, crowns or implants)
- Aggregatibacter actinomycetemcomitans-positive
Exclusion
- Systemic illnesses (i.e. diabetes mellitus, cancer, HIV, bone metabolic diseases or disorders that compromise wound healing, radiation or immunosuppressive therapy)
- Pregnancy or lactation
- Systemic antibiotics taken within the previous two months
- Use of non-steroid anti-inflammatory drugs
- Confirmed or suspected intolerance to 5-nitroimidazole-derivatives or amoxicillin subgingival SRP or surgical periodontal therapy in the last year
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2014
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT02197260
Start Date
September 1 2008
End Date
March 1 2014
Last Update
July 22 2014
Active Locations (1)
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1
University of Geneva School of Dental Medicine
Geneva, Canton of Geneva, Switzerland, CH-1205