Status:
UNKNOWN
Impact of Presurgical Exercise on Hemodialysis Fistula Outcomes
Lead Sponsor:
University Health Network, Toronto
Conditions:
Chronic Kidney Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this research study is to determine whether two different types of forearm exercise, performed before fistula creation surgery, can improve surgery success and fistula maturation.
Detailed Description
This is a randomized, double blinded controlled trial to study the impact of handgrip exercise prior to surgical creation of hemodialysis fistula on vascular remodelling and fistula maturation in chro...
Eligibility Criteria
Inclusion
- Adult (age\>18 years old) with chronic kidney disease
- Hemodialysis is their renal replacement therapy (RRT) modality
- Deemed eligible for an arteriovenous fistula
- Anticipated RRT start \< 3 months (from the time of vascular surgery assessment) if predialysis
- Scheduled surgical creation of fistula aniticpated \>= 8 weeks
- Able to follow instructions for an exercise intervention
- Able to provide informed written consent
Exclusion
- Life expectancy \< 6 months
- Need for urgent vascular access (i.e. \<4 weeks)
- Pre-existing fistula distal to site of newly scheduled fistula
- Ipsilateral central stenosis or occlusions not amenable to correction
- Contraindications or unable to perform handgrip exercise
- Unable to withstand transiently raised systolic blood pressure (SBP) by 35 mmHg, and diastolic (DBP) by 25 mmHg
- severe upper extremity arthritis or other pain
- Contraindications to general exercise
- Poorly controlled blood pressure - SBP\>180, DBP\>90; SBP\<110, DBP\<50
- NYHC IV heart failure
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2018
Estimated Enrollment :
210 Patients enrolled
Trial Details
Trial ID
NCT02205944
Start Date
September 1 2014
End Date
March 1 2018
Last Update
July 6 2016
Active Locations (1)
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1
Toronto General Hospital - UHN
Toronto, Ontario, Canada, M5G 2C4