Status:
COMPLETED
Cognition and Obstructive Sleep Apnea in Parkinson's Disease, Effect of Positive Airway Pressure Therapy
Lead Sponsor:
McGill University Health Centre/Research Institute of the McGill University Health Centre
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
American Thoracic Society
Conditions:
Parkinson's Disease
Obstructive Sleep Apnea
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Cognitive dysfunction (impaired memory, thinking, etc) frequently occurs in Parkinson's disease (PD), often progresses to dementia, and profoundly affects quality of life. Obstructive sleep apnea (OSA...
Eligibility Criteria
Inclusion
- Parkinson's disease as perMDS criteria
- Evidence of cognitive dysfunction (clinical impression of mild cognitive impairment and MOCA \<=27)
- Presence of OSA (apnea-hypopnea index RDI ≥ 15/h) on screening diagnostic polysomnography (PSG)
- Stable regimen of anti-PD medication for 1 month prior
- Adequate knowledge of English or French for completion of study assessment.
Exclusion
- Oxygen saturation \<75% for \>10% of the diagnostic polysomnography as this should lead to active PAP treatment
- Other major neurological disorder
- Unstable cardiac disease, uncontrolled hypertension, or diabetes
- Active cancer or other disorder with an expected survival \< 6 months
- Active treatment of OSA (prior diagnosis of OSA will constitute an exclusion criterion only if the patient is currently being treated for the OSA)
- Significant vision or hearing impairment that could affect performance on neurocognitive assessment tasks.
- Latex allergy.
Key Trial Info
Start Date :
April 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2022
Estimated Enrollment :
91 Patients enrolled
Trial Details
Trial ID
NCT02209363
Start Date
April 1 2015
End Date
December 1 2022
Last Update
March 13 2024
Active Locations (3)
Enter a location and click search to find clinical trials sorted by distance.
1
Jewish General Hospital
Montreal, Quebec, Canada
2
McGill University Health Centre
Montreal, Quebec, Canada
3
Montreal Neurological Hospital and Institute
Montreal, Quebec, Canada