Status:
COMPLETED
ENdothelial DysfUnction in Renal Disease and Exercise Training
Lead Sponsor:
Universiteit Antwerpen
Conditions:
Chronic Kidney Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Chronic kidney disease (CKD) is a prevalent disorder and a major health concern. Cardiovascular disease is the most prevailing and life-threatening complication observed in patients with CKD. The diag...
Eligibility Criteria
Inclusion
- patients with CKD stage 3-4 (eGFR (15-59 ml/min/1.73m2) without cardiovascular disease.
Exclusion
- patients \< 18 years
- pregnancy
- warfarin therapy
- glucocorticoid therapy
- clinically active malignant disease
- heart failure (ejection fraction \< 50%)
- peripheral vascular disease, defined as a history of intermittent claudication, abnormal peripheral angiography or Doppler ultrasound, lower limb artery bypass surgery/angioplasty/stenting or non-traumatic lower extremity amputation
- cerebrovascular disease, defined as a history of transient ischemic attack (TIA) or stroke, significant stenosis of the A. carotis on ultrasound/CT angiography or carotid endarterectomy/stenting
- coronary artery disease (CAD), defined as a history of myocardial infarction, coronary artery angioplasty/stenting/bypass surgery, significant structural coronary lesions on angiography or high suspicion of CAD on a maximal exercise test
Key Trial Info
Start Date :
April 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2014
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT02209402
Start Date
April 1 2012
End Date
May 1 2014
Last Update
August 5 2014
Active Locations (1)
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1
Antwerp University Hospital
Antwerp, Antwerp, Belgium, 2650