Status:
COMPLETED
RCT of Continuous Versus Intermittent Infusion of Vancomycin in Neonates
Lead Sponsor:
Murdoch Childrens Research Institute
Collaborating Sponsors:
Royal Children's Hospital
Royal Hospital For Women
Conditions:
Sepsis
Infection
Eligibility:
All Genders
Up to 90 years
Phase:
NA
Brief Summary
Babies aged 0 to 90 days with a suspected infection requiring treatment with vancomycin will be recruited. They will be randomised to receive vancomycin as an intermittent infusion (over 1 hour) or as...
Eligibility Criteria
Inclusion
- \- Neonates in the neonatal unit with an infection requiring treatment with vancomycin as determined by the treating physician.
Exclusion
- Infants with a corrected gestational age \< 25 weeks.
- Allergy to vancomycin or other glycopeptide antibiotic
- Vancomycin administered within the previous 72 hours
- Renal impairment
- Prior enrolment in the study
- Need for drug that is incompatible with vancomycin (if no other IV line is available)
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2018
Estimated Enrollment :
111 Patients enrolled
Trial Details
Trial ID
NCT02210169
Start Date
September 1 2014
End Date
May 1 2018
Last Update
November 2 2018
Active Locations (2)
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1
Royal Hospital for Women
Sydney, New South Wales, Australia, 2031
2
The Royal Children's Hospital
Melbourne, Victoria, Australia, 3052