Status:
COMPLETED
Comparison of Autologous Platelet-rich Plasma With Hyaluronic Acid for the Treatment of Osteoarthritis of the Knee Joint
Lead Sponsor:
Samsung Medical Center
Conditions:
Osteoarthritis, Knee
Eligibility:
All Genders
40-80 years
Phase:
PHASE3
Brief Summary
The purpose of this study is to compare the efficacy of platelet-rich plasma versus hyaluronic acid intra-articular injections for the treatment of osteoarthritis of knee joint. The hypothesis is tha...
Detailed Description
Osteoarthritis (OA) has a significant impact on our society. The limited regenerative capacity of cartilage is part of this problem. Existing degenerative lesions lead to accelerated deterioration of ...
Eligibility Criteria
Inclusion
- Patients with osteoarthritis of knee (by American College of Rheumatology Criteria) and Kellgren-Lawrence grade I \~ III
- More than 40 out of 100-mm VAS scale for pain at screening and baseline
- Participant is willing and able to give informed consent for participation in the study
Exclusion
- Patients with Hb values \< 10 g/dl and platelet values \< 100,000/ul
- Patients with a current or medical history of autoimmune disease
- Recent fever ( within 2 weeks) or serious illness
- Local infection at the site of the procedure
- Corticosteroid injection at treatment site within 1 month
- Systematic use of corticosteroids within 2 weeks
- Female participants who are pregnant, lactating or planning pregnancy during the course of the study
- Patients who have been administered with immunosuppressants within the past 6 weeks
- Patients who are enrolled in any other clinical trials within 4 weeks
- Patients who the principal investigator considers inappropriate for participation in the clinical trial for reasons other than those listed above
Key Trial Info
Start Date :
August 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2015
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT02211521
Start Date
August 1 2014
End Date
October 1 2015
Last Update
December 10 2015
Active Locations (1)
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1
Samsung Medical Center
Seoul, South Korea, 135-710