Status:
COMPLETED
Electronic Cigarettes in Smokers With Mental Illness
Lead Sponsor:
King's College London
Conditions:
Schizophrenia
Schizophreniform Disorder
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
People with mental illness are more likely to smoke and are more severely addicted to nicotine than the general population. As a result, the number of deaths related to tobacco is higher. Smoking is ...
Eligibility Criteria
Inclusion
- smokers (≥ 5 cigarettes/day for \> 1 yr and breath CO \> 5 ppm)
- ages 18-65 years
- ICD-10 diagnosis of schizophreniform, schizophrenia, schizoaffective or bipolar disorder
Exclusion
- used e-cigs on \> 2 occasions in the past 30 days;
- intend to quit smoking within the next 30 days;
- currently use medications that may reduce smoking (bupropion, varenicline, NRT, naltrexone, buprenorphine, acamprosate, baclofen, clonidine, nortriptyline, anti-seizure medications, disulfiram);
- have unstable psychiatric conditions (hospitalization or change in dose of chronic medication in the past 30 days);
- People with a serious medical condition including uncontrolled high blood pressure, something wrong with their heart or blood vessels that occurred or got worse in the past 3 months (including fast or irregular heart rhythm, angina, chest pain, had a heart attack or stroke).
- People who have ever had a serious stomach ulcer, and/or phaeochromocytoma (tumor of the adrenal gland).
- People who in the last 3 months have had severe heartburn; or a stroke, or unstable kidney disease, unstable liver disease, uncontrolled over-active thyroid gland
- met DSM-IV criteria for drug dependence
- have medical contraindications to nicotine, since nicotine intake may increase in this study;
- have past-month suicidal ideation or past-year suicide attempt.
- are pregnant, as determined through a pregnancy test
Key Trial Info
Start Date :
September 24 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 2 2017
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT02212041
Start Date
September 24 2014
End Date
May 2 2017
Last Update
May 16 2017
Active Locations (1)
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1
South London and Maudsley Foundation Trust (SLaM)
London, United Kingdom, SE5 8AF