Status:
COMPLETED
Antioxidant Signature in Adult Patients With Phenylketonuria
Lead Sponsor:
University Hospital, Tours
Collaborating Sponsors:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
PKU
Hyperphenylalaninemia
Eligibility:
All Genders
18-65 years
Brief Summary
To date, oxidative stress in PKU has been evaluated only with fragmented approaches.The aim of the present study is to investigate oxidative stress in PKU with more comprehensive methods.The relations...
Detailed Description
Analysis of oxidative stress Oxidative metabolism is most likely disrupted leukocytes in the PCU thereof having DNA breaks correlated to blood Phe levels (22). Accessibility by patients, these cells ...
Eligibility Criteria
Inclusion
- PKU patients over 18 years of age with phenylketonuria not treated with a phenylalanine-controlled diet.
- Affiliation to a social security scheme
- Reading and signing the informed consent
- Control subjects: all healthy subjects over 18 years of unfulfilled abnormal metabolism of whatever nature and associated symptoms
Exclusion
- Pregnancy of patients and control subjects women (confirmed by a negative pregnancy test)
- Patients with diseases that may cause oxidative stress (neurodegenerative diseases, cancer)
- Patients treated with drugs known to cause oxidative stress
- Control subjects:controlled protein diet
Key Trial Info
Start Date :
September 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2015
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT02212288
Start Date
September 1 2014
End Date
January 1 2015
Last Update
January 16 2017
Active Locations (1)
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1
University Hospital of TOURS
Tours, I&L, France, 37044