Status:
COMPLETED
Spatial Orientation and Vestibular Function
Lead Sponsor:
University of Zurich
Conditions:
Vestibular Perception
Damaged Vestibular System
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Spatial orientation is achieved through central integration of various sensory inputs and prior knowledge in a statistically optimal way based on the reliability of the different signals. When upright...
Eligibility Criteria
Inclusion
- ages 18-75
- informed consent
- for group 1: acute (i.e. symptom onset less than 72 hours ago) unilateral vestibular deficit as confirmed by clinical examination (pathologic head-impulse test, no skew deviation, no gaze-evoked nystagmus).
- for group 2: chronic (i.e. symptom onset more than 4 weeks ago) unilateral vestibular deficit as confirmed by vestibular testing in the acute stage (either abnormal unilateral response on caloric irrigation or video-head-impulse testing).
- for group 3: chronic (i.e. symptom onset more than 4 weeks ago) bilateral vestibular deficits as confirmed by vestibular testing (bilaterally reduced response on caloric irrigation or video-head impulse testing).
- absence of exclusion criteria
Exclusion
- History of a peripheral-vestibular deficit (valid only for group 4 - controls)
- Disturbed consciousness
- Personal history of traumatic brain injury, cerebrovascular disorders, seizures
- History of chronic neck complaints including severe neck pain.
- Alcohol dependency
- Intake of anxiolytic, antidepressant, neuroleptic or sedative medication
- Other neurological or systemic disorder which can cause cerebellar deficits, dementia, cognitive dysfunction, visuospatial or tactile neglect, aphasia or visual field deficits
- Pregnancy or possible pregnancy if not ruled out by a negative pregnancy test.
Key Trial Info
Start Date :
July 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 28 2018
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT02212847
Start Date
July 1 2013
End Date
June 28 2018
Last Update
July 2 2018
Active Locations (1)
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1
University Hospital Zurich, Division of Neurology
Zurich, Canton of Zurich, Switzerland, 8091