Status:
WITHDRAWN
Using Ripple Mapping to Guide Substrate Ablation of Scar Related Ventricular Tachycardia.
Lead Sponsor:
Imperial College London
Conditions:
Monomorphic Ventricular Tachycardia
Myocardial Infarction
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
The heart beat is controlled by electrical signals. Following a heart attack, part of the heart muscle dies and is later replaced by scar tissue. Within this area of scar, there often remain "channels...
Detailed Description
In patients with a previous heart attack, the scar formed in the left ventricle (bottom chamber of the heart) consists of dead tissue mixed with strands of live tissue which form "conduction channels"...
Eligibility Criteria
Inclusion
- Evidence of VT (shock/ anti tachycardia pacing/ detection) on ICD (single, dual or bi-ventricular) interrogation or 12 lead ECG.
- Presumed scar related VT post myocardial infraction infarct/ dilated cardiomyopathy.
- Age range 18-85yrs.
- ICD implantation for primary or secondary prophylaxis, or device implantation pre-discharge from hospital post ablation procedure.
- Signed informed consent
Exclusion
- Contraindication to catheter ablation
- Coronary revascularisation required
- Ventricular tachycardia due to transient, reversible causes
- Presence of cardiac thrombus
- Severe cerebrovascular disease
- Active gastrointestinal disease
- Renal failure with creatinine \>200 μmol/L or on dialysis
- Active fever or infection
- Life expectancy shorter than the trial
- Allergy to contrast
- Intractable heart failure (NYHA Class IV)
- Bleeding or clotting disorders or inability to receive heparin
- Pregnancy
- Must not have previous (4 weeks prior to screening) or current participation in another clinical trial with an investigational drug or investigational device
- Unable to give informed consent
- Unable to attend follow-up visits or ICD clinics
Key Trial Info
Start Date :
August 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2018
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT02216760
Start Date
August 1 2014
End Date
August 1 2018
Last Update
May 16 2019
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Hammersmith Hospital, Imperial College Healthcare NHS Trust
London, United Kingdom, W12 0HS