Status:
COMPLETED
Impact of Weight Loss After a Bypass Surgery on Renal Hemodynamic Under Stress Conditions
Lead Sponsor:
Centre Hospitalier Universitaire Vaudois
Conditions:
Obesity
Bariatric Surgery
Eligibility:
All Genders
18-65 years
Brief Summary
The sympathetic nervous (SNS) and the renin angiotensin aldosterone system (RAS) have a direct impact on renal hemodynamic, hormonal secretion and vasoactive peptide. Many mechanisms including the SNS...
Eligibility Criteria
Inclusion
- BMI \>35 Kg/m2
- Understanding and signing the informed consent
- Estimated glomerular filtration rate \>60 ml/min/1.73 m2
Exclusion
- Acute disease
- Asthma or history of asthma
- Patient participating in another clinical trial 30 days before the beginning of the study
- Blood donation (450ml) 2 months before the beginning of the study
- Chronic medication which influence renal function (NSAIDS, Others)
- Allergy
- Documented renal arterial stenosis
- History of symptomatic orthostatic hypotension
- Kidney transplantation
- Kidney malformation / polycystic kidney disease
- Impaired judgement
- Liver failure with ascitis
- Hip circumference at the upper anterior iliac spine \> 130cm
- Waist circumference \>180cm and weighing \> 220kg
- Contraindication/Allergy to furosemide, PAH or Inulin
- Contraindication to MRI if the patient is going to undergo BOLD-MRI
- Postprandial glycemia \> 11.0 mmol/L in diabetic patients
- Blood pressure \> 180/110 assessed by 24 hour blood pressure measurement
Key Trial Info
Start Date :
June 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 31 2017
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT02218112
Start Date
June 1 2014
End Date
July 31 2017
Last Update
March 16 2018
Active Locations (1)
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1
Centre Hospitalier Universitaire Vaudois
Lausanne, Canton of Vaud, Switzerland, 1004