Status:
UNKNOWN
Ketamine Prevent POCD
Lead Sponsor:
RenJi Hospital
Conditions:
Necrosis of Femoral Head
Knee Osteoarthritis
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
Previous study demonstrated that neuroinflammation induced by surgery is the main cause of the postoperative cognitive dysfunction. As an agonist of NMDA receptor, ketamine is proved to be an anti-inf...
Eligibility Criteria
Inclusion
- Elder than 60
- Easily communicated with Chinese
- Selected to kneel or hip replacement
- Agree to take part into this clinical trail
Exclusion
- Existing cerebral disease， or have a history of neurological and psychiatric disease including AD, stroke and psychosis
- Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
- Several audition or vision disorder
- Preoperative systolic Blood pressure over 190mmHg or diastolic pressure \>100mmHg
- Existing a history of hyperthyroidism
- Patient with glaucoma
- Unwillingness to comply with the protocol or procedures
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2016
Estimated Enrollment :
484 Patients enrolled
Trial Details
Trial ID
NCT02220400
Start Date
September 1 2014
End Date
September 1 2016
Last Update
August 19 2014
Active Locations (3)
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1
Shanghai Tongji Hospital
Shanghai, Shanghai Municipality, China, 200065
2
Renji Hospital, School of Medicine, Shanghai Jiaotong University
Shanghai, Shanghai Municipality, China, 200127
3
Shanghai Pudong New Area People's Hospital
Shanghai, Shanghai Municipality, China