Status:
TERMINATED
Effects of Donepezil on Regional Cerebral Blood Flow Following Aneurysmal Subarachnoid Haemorrhage
Lead Sponsor:
St George's, University of London
Conditions:
Aneurysmal Subarachnoid Hemorrhage
Delayed Neurological Deficit
Eligibility:
All Genders
18-85 years
Phase:
PHASE2
Brief Summary
Introduction Aneurysmal subarachnoid hemorrhage (aSAH) is bleeding around the under surface of the brain caused by rupture of an aneurysm arising from a blood vessel. Stroke may occur in approximatel...
Eligibility Criteria
Inclusion
- age 18 - 85 years
- Fisher score 2-4
- recruitment within 12 - 72 hours of hemorrhage
Exclusion
- pregnancy
- breast feeding
- allergy to donepezil or other piperidine derivatives
- participants unwilling to use appropriate birth control up to 6 weeks after enrolment
- known dementia
- severe liver failure (Child-Pugh C)
- sick sinus syndrome or other supraventricular cardiac conduction abnormalities
- inspired oxygen requirement greater than 60%
- history of brittle asthma or obstructive airway disease
- aneurysm unsuitable for endovascular coiling
- concomitant use of cholinesterase inhibitor (e.g. rivastigmine, galantamine, etc)
Key Trial Info
Start Date :
January 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2016
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT02222727
Start Date
January 1 2014
End Date
November 1 2016
Last Update
September 11 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
St George's University of London
London, United Kingdom, SW17 0RE