Status:
COMPLETED
Antiplatelet Therapy After Cardiac Arrest
Lead Sponsor:
University Medical Centre Ljubljana
Conditions:
Cardiac Arrest
Postresuscitation Syndrome
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
There is growing evidence that standard dual antiplatelet therapy with acetylsalicylic acid (ASA) and clopidogrel is not as effective in the setting of therapeutic hypothermia after cardiac arrest as ...
Eligibility Criteria
Inclusion
- Female and male over 18 years old
- Unconscious survivors of cardiac arrest treated with therapeutic hypothermia
- Acute coronary syndrome (NSTEMI or STEMI) as a reason of cardiac arrest
- PCI with stent implantation
- Provision of informed consent prior to any study specific procedures is impossible because subjects are unconscious at the moment of inclusion
Exclusion
- Use of any P2Y12 inhibitors in last 10 days
- Use of prasugrel before and 48 hours after loading dose of P2Y12 inhibitor
- Use of eptifibatide before and 48 hours after loading dose of P2Y12 inhibitor
- Thrombocytopenia (\<50\*109/L)
- Allergic reaction to acetylsalicylic acid, clopidogrel or ticagrelor
- Ticagrelor contraindications: previous intracranial bleeding, active pathological bleeding, moderate to severe hepatic impairment, heart rate \< 40/min at presentation
- Suspected or confirmed pregnancy
- Use of bivalirudin before and 48 hours after loading dose of P2Y12 inhibitor
Key Trial Info
Start Date :
August 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2016
Estimated Enrollment :
57 Patients enrolled
Trial Details
Trial ID
NCT02224274
Start Date
August 1 2014
End Date
June 1 2016
Last Update
February 27 2019
Active Locations (1)
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1
University Medical Centre Ljubljana
Ljubljana, Slovenia, 1000