Status:
COMPLETED
Effect of Intense Training on Ovarian Function and Bone Turnover
Lead Sponsor:
USDA, Western Human Nutrition Research Center
Collaborating Sponsors:
University of California, Davis
Conditions:
Amenorrhea
Eligibility:
FEMALE
18-40 years
Phase:
NA
Brief Summary
The investigators propose a prospective, longitudinal, department funded study protocol to evaluate whether changes in energy availability, during a period of highly intensified exercise training, wil...
Detailed Description
Female athletes participating in sports which emphasize leanness as a factor to success, while also imposing large exercise training loads, present a high prevalence of endocrine and metabolic alterat...
Eligibility Criteria
Inclusion
- competitive endurance runners (racing in events ranging from 10km to ultra-marathons)
- training at least 5 days per week over the past 12 months, and more than 30 miles per week
- regular menstrual cycles (24-35 days) over the past 6 months
- maximal oxygen consumption (VO2max) \> 50ml/kg/min
- English speaking
Exclusion
- smoker
- amenorrhea
- pregnant or lactating in the past 2 years
- chronic disease that will affect bone health, metabolism or the cardiorespiratory system
- take medications that have cardiovascular or metabolic effects
- present any contra-indication to exercise testing (cardiovascular abnormalities)
- report any major illness or injury preventing training for more than 4 weeks over the past 3 months
- a history of clinical anorexia nervosa or bulimia nervosa
Key Trial Info
Start Date :
January 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2015
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT02224976
Start Date
January 1 2014
End Date
December 1 2015
Last Update
January 28 2016
Active Locations (1)
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1
USDA Western Human Nutrition Research Center
Davis, California, United States, 95616