Status:
TERMINATED
Effect of HBO on Functional Connectivity of Resting State Networks in Patients With Cerebral Small Vessel Disease
Lead Sponsor:
St. Luke's Hospital, Chesterfield, Missouri
Collaborating Sponsors:
Washington University School of Medicine
Conditions:
Encephalopathy
White Matter Hyperintensities
Eligibility:
All Genders
50-90 years
Phase:
NA
Brief Summary
The purpose of this study is to extend our previous work, in which we demonstrated an increase in the internal and cross network connectivity of resting state neural networks in patients with cerebral...
Detailed Description
Patients without contraindications to Hyperbaric Oxygen treatment or magnetic resonance imaging who exhibit white matter hyper-intensities on MRI will be recruited to have a functional MRI followed by...
Eligibility Criteria
Inclusion
- Over 50 years of age White Matter Hyperintensities on MRI @ or more symptoms and/or neurological impairments e.g. gait disturbances,disequilibrium, decline in cognitive function, upper motor neuron deficit, dysmetria, hyper-refexia or unilateral increase in motor tone -
Exclusion
- Contraindications to hyperbaric oxygen therapy e.g. pulmonary emphysema or bullae, claustrophobiia, seizure diorder Inability of the patient to tolerate pressurization e.g. Eustachian tube dysfunction Stroke within the previous 6 months Extreme cognitive impairment Major depression Other uncontrolled co-morbidities, e.g. diabetes, hypertension, thyroid disorders, carotid artery stenosis (\>70%), renal or hepatic dysfunction History of brain tumor, head trauma, electric shock therapy, brain irradiation History of migraine headaches
- \-
Key Trial Info
Start Date :
September 16 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 4 2017
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT02232958
Start Date
September 16 2014
End Date
October 4 2017
Last Update
October 30 2017
Active Locations (3)
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1
St. Luke's Hospital
Chesterfield, Missouri, United States, 63017
2
St. Luke's Hospital
St Louis, Missouri, United States, 63017
3
Mallinckrodt Institute of Radiology/Washington University Medical School
St Louis, Missouri, United States, 63110